Observational Study of PD-L1, TGF-β, and Immune Cell Infiltrates in Hepatocellular Carcinoma

Introduction: Hepatocellular carcinoma (HCC) typically develops in cirrhotic livers, with increased programed death ligand 1 (PD-L1) and transforming growth factor beta (TGF-β) activity implicated in immunosuppression.Methods: In an observational study of HCC liver samples, we determined the inciden...

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Autores principales: Christian Ihling, Bartholomew Naughton, Yue Zhang, P. Alexander Rolfe, Eveline Frick-Krieger, Luigi M. Terracciano, Isabelle Dussault
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019-02-01
Colección:Frontiers in Medicine
Materias:
PD-L1
checkpoint inhibitor
CD8
immune cell infiltrates
hepatocellular carcinoma
HCC
Acceso en línea:https://www.frontiersin.org/article/10.3389/fmed.2019.00015/full
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