THE INVOLVEMENT PROPROTEIN CONVERTASE SUBTILISIN/KEXIN OF TYPE 9 IN THE PATHOGENESIS OF ATHEROSCLEROSIS (LITERATURE REVIEW)

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is now considered an important contributor to the pathogenesis of atherosclerosis. The article describes the history of the discovery of PCSK9, the structure, functions and stages of biosynthesis of this molecule. PCSK9, through promoting lyso...

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Bibliographic Details
Main Author: A. M. Chaulin
Format: Artigo
Language:Inglês
Published: Penza State University Publishing House 2020-03-01
Series:Известия высших учебных заведений. Поволжский регион: Медицинские науки
Subjects:
proprotein convertase subtilisin/kexin type 9 (pcsk9)
atherosclerosis
cholesterol
low-density lipoproteins (ldl)
low-density lipoprotein receptors (ldlr)
inflammation
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