Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways

Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined the effects of SV on the functional activity of α7nAChR on CA1 pyramidal cells using patch-clamp recording and ex...

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Autori principali: Tingting Chen, Ya Wang, Tingting Zhang, Baofeng Zhang, Lei Chen, Liandong Zhao, Ling Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018-04-01
Serie:Frontiers in Pharmacology
Soggetti:
simvastatin
α7 nicotinic acetylcholine receptor (α7nAChR)
farnesyl pyrophosphate (FPP)
farnesyl transferase inhibitor (FTI)
protein kinas C (PKC)
calmodulin-kinase II (CaMKII)
Accesso online:http://journal.frontiersin.org/article/10.3389/fphar.2018.00362/full
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