HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (<it>cis</it>-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

<p>Abstract</p> <p>Background</p> <p>Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, thereby compromising p53 activity. Therefore, lymphoma is a suitable model for studying the therapeutic value of disrupting the HDM2-p53 interaction by sma...

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Bibliographic Details
Main Authors: Sosin Angela M, Burger Angelika M, Siddiqi Aisha, Abrams Judith, Mohammad Ramzi M, Al-Katib Ayad M
Format: Artigo
Language:Inglês
Published: BMC 2012-09-01
Series:Journal of Hematology & Oncology
Subjects:
HDM2
p53
Apoptosis
MI-219
Nutlin-3
B-cell lymphoma
Small-molecule inhibitor
Autoubiquitination
Online Access:http://www.jhoonline.org/content/5/1/57
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