HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (<it>cis</it>-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

<p>Abstract</p> <p>Background</p> <p>Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, thereby compromising p53 activity. Therefore, lymphoma is a suitable model for studying the therapeutic value of disrupting the HDM2-p53 interaction by sma...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Sosin Angela M, Burger Angelika M, Siddiqi Aisha, Abrams Judith, Mohammad Ramzi M, Al-Katib Ayad M
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMC 2012-09-01
Serie:Journal of Hematology & Oncology
Ämnen:
HDM2
p53
Apoptosis
MI-219
Nutlin-3
B-cell lymphoma
Small-molecule inhibitor
Autoubiquitination
Länkar:http://www.jhoonline.org/content/5/1/57
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk