HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (<it>cis</it>-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

<p>Abstract</p> <p>Background</p> <p>Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, thereby compromising p53 activity. Therefore, lymphoma is a suitable model for studying the therapeutic value of disrupting the HDM2-p53 interaction by sma...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Sosin Angela M, Burger Angelika M, Siddiqi Aisha, Abrams Judith, Mohammad Ramzi M, Al-Katib Ayad M
Format: Artigo
Jezik:Inglês
Izdano: BMC 2012-09-01
Serija:Journal of Hematology & Oncology
Teme:
HDM2
p53
Apoptosis
MI-219
Nutlin-3
B-cell lymphoma
Small-molecule inhibitor
Autoubiquitination
Online pristup:http://www.jhoonline.org/content/5/1/57
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items