Core-shell hydrogel particles harvest, concentrate and preserve labile low abundance biomarkers.

The blood proteome is thought to represent a rich source of biomarkers for early stage disease detection. Nevertheless, three major challenges have hindered biomarker discovery: a) candidate biomarkers exist at extremely low concentrations in blood; b) high abundance resident proteins such as albumi...

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Bibliographic Details
Main Authors: Caterina Longo, Alexis Patanarut, Tony George, Barney Bishop, Weidong Zhou, Claudia Fredolini, Mark M Ross, Virginia Espina, Giovanni Pellacani, Emanuel F Petricoin, Lance A Liotta, Alessandra Luchini
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2651577?pdf=render
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