Rofecoxib Attenuates the Pathogenesis of Amyotrophic Lateral Sclerosis by Alleviating Cyclooxygenase-2-Mediated Mechanisms

Cyclooxygenase-2 (COX-2) is reported to be activated during the course of amyotrophic lateral sclerosis (ALS) development and progression. However, the roles of COX-2 in aggravating ALS and the underlying mechanism have been largely overlooked. To reveal the mechanisms, the canonical SOD1G93A mouse...

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Bibliographic Details
Main Authors: Yan-Hui Zou, Pei-Pei Guan, Shen-Qing Zhang, Yan-Su Guo, Pu Wang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
cyclooxygenase-2
neuroinflammation
refecoxib
ALS
mechanism
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00817/full
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