Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer

Abstract Background Previous studies have shown a major green tea polyphenol (−)-epigallocatechin-3-gallate ((−)-EGCG) as a powerful anti-cancer agent. However, its poor bioavailability and requirement of a high dosage to manifest activity have restricted its clinical application. Recently, our team...

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Hlavní autoři: Gene Chi Wai Man, Jianzhang Wang, Yi Song, Jack Ho Wong, Yu Zhao, Tat San Lau, Kam Tong Leung, Tak Hang Chan, Huating Wang, Joseph Kwong, Tzi Bun Ng, Chi Chiu Wang
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2020-10-01
Edice:BMC Cancer
Témata:
ProEGCG
Endometrial cancer
Apoptosis
Anticancer
Anti-angiogenesis
Akt pathway
On-line přístup:http://link.springer.com/article/10.1186/s12885-020-07455-3
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