8-Cl-Adenosine-Induced Inhibition of Colorectal Cancer Growth In Vitro and In Vivo

The cAMP analogue 8-Cl-cAMP induces apoptosis and inhibits proliferation of a wide variety of malignancies in vitro and in vivo with relatively little toxicity. The antitumor effects of this compound are thought to involve its ability to modulate type I protein kinase A (PKAI). However, a nontoxic m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chris C. Carlson, Rebecca Chinery, Laura L. Burnham, Daniel T. Dransfield
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2000-09-01
Schriftenreihe:Neoplasia: An International Journal for Oncology Research
Schlagworte:
8-Cl-adenosine
colorectal cancer
cell cycle
endoreduplication
xenograft
Online Zugang:http://www.sciencedirect.com/science/article/pii/S1476558600800147
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