Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

<p>Abstract</p> <p>Background</p> <p>Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly people over 60. The pathogenesis is still unclear. It has been suggested that lysosomal stress may lead to drusen formation, a biomarker of AMD. In...

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Bibliographic Details
Main Authors: Chen Patrick M, Gombart Zoë J, Chen Jeff W
Format: Artigo
Language:Inglês
Published: BMC 2011-03-01
Series:Cell & Bioscience
Online Access:http://www.cellandbioscience.com/content/1/1/10
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