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A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1α in a Von Hippel-Lindau Renal Oncocytoma

The Von Hippel-Lindau (VHL) syndrome has been rarely associated with renal oncocytomas, and tumors usually show HIF1α chronic stabilization. By contrast, oncocytomas mainly associated with respiratory chain (RC) defects due to severe mitochondrial DNA (mtDNA) mutations are incapable of stabilizing H...

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Hlavní autoři: Monica De Luise, Vito Guarnieri, Claudio Ceccarelli, Leonardo D’Agruma, Anna Maria Porcelli, Giuseppe Gasparre
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Limited 2019-01-01
Edice:Oxidative Medicine and Cellular Longevity
On-line přístup:http://dx.doi.org/10.1155/2019/8069583
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