Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage.

This study examines the regulating effect of Sonic Hedgehog (Shh) on the permeability of the blood-brain barrier (BBB) in cerebral ischemia. By employing permanent middle cerebral artery occlusion (pMCAO) model, we find that Shh significantly decreases brain edema and preserves BBB permeability. Mor...

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Hlavní autoři: Yuan-peng Xia, Quan-wei He, Ya-nan Li, Sheng-cai Chen, Ming Huang, Yong Wang, Yuan Gao, Yan Huang, Meng-die Wang, Ling Mao, Bo Hu
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2013-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3720889?pdf=render
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