Ketamine Alleviates Postoperative Depression-Like Symptoms in Susceptible Mice: The Role of BDNF-TrkB Signaling

Patients are more likely to suffer from central nervous system (CNS) complications after anesthesia and surgery. However, postoperative depression (POD) has not yet received sufficient attentions, and its pathogenesis and therapeutic strategies remain poorly understood. We here aimed to investigate...

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Autori principali: Shan Li, Xiaoxiao Luo, Dongyu Hua, Yue Wang, Gaofeng Zhan, Niannian Huang, Riyue Jiang, Ling Yang, Bin Zhu, Xianglin Yuan, Ailin Luo, Chun Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-02-01
Serie:Frontiers in Pharmacology
Soggetti:
postoperative depression
ketamine
BDNF-TrkB signaling
elderly
sex difference
Accesso online:https://www.frontiersin.org/article/10.3389/fphar.2019.01702/full
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