Differential DNA methylation at conserved non-genic elements and evidence for transgenerational inheritance following developmental exposure to mono(2-ethylhexyl) phthalate and 5-azacytidine in zebrafish

Abstract Background Exposure to environmental stressors during development may lead to latent and transgenerational adverse health effects. To understand the role of DNA methylation in these effects, we used zebrafish as a vertebrate model to investigate heritable changes in DNA methylation followin...

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Bibliographic Details
Main Authors: Jorke H. Kamstra, Liana Bastos Sales, Peter Aleström, Juliette Legler
Format: Artigo
Language:Inglês
Published: BMC 2017-04-01
Series:Epigenetics & Chromatin
Subjects:
Phthalate
5-Azacytidine
Epigenetics
DNA methylation
Transgenerational
Zebrafish
Online Access:http://link.springer.com/article/10.1186/s13072-017-0126-4
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