Dexmedetomidine Exerted Anti-arrhythmic Effects in Rat With Ischemic Cardiomyopathy via Upregulation of Connexin 43 and Reduction of Fibrosis and Inflammation

BackgroundPersistent myocardial ischemia post-myocardial infarction can lead to fatal ventricular arrhythmias such as ventricular tachycardia and fibrillation, both of which carry high mortality rates. Dexmedetomidine (Dex) is a highly selective α2-agonist used in surgery for congenital cardiac dise...

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Hauptverfasser: Shu-jie Wu, Zhong-hao Lin, Yuan-zheng Lin, Zhi-heng Rao, Jia-feng Lin, Lian-pin Wu, Lei Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-02-01
Schriftenreihe:Frontiers in Physiology
Schlagworte:
dexmedetomidine
ischemic cardiomyopathy
ventricular arrhythmia
inflammation
fibrosis
Online Zugang:https://www.frontiersin.org/article/10.3389/fphys.2020.00033/full
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