Pharmacological Inhibition of PPAR<sub>y</sub> Boosts HIV Reactivation and Th17 Effector Functions, while Preventing Progeny Virion Release and <i>de novo</i> Infection

The frequency and functions of Th17-polarized CCR6+RORyt+CD4+ T cells are rapidly compromised upon HIV infection and are not restored with long-term viral suppressive antiretroviral therapy (ART). In line with this, Th17 cells represent selective HIV-1 infection targets mainly at mucosal sites, with...

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Main Authors: Delphine Planas, Augustine Fert, Yuwei Zhang, Jean-Philippe Goulet, Jonathan Richard, Andrés Finzi, Maria Julia Ruiz, Laurence Raymond Marchand, Debashree Chatterjee, Huicheng Chen, Tomas Raul Wiche Salinas, Annie Gosselin, Eric A. Cohen, Jean-Pierre Routy, Nicolas Chomont, Petronela Ancuta
Formato: Artigo
Idioma:Inglês
Publicado: Case Western Reserve University 2020-09-01
Series:Pathogens and Immunity
Assuntos:
hiv-1
art
cd4+ t cells
th17
ppary
il-21
Acceso en liña:https://paijournal.com/index.php/paijournal/article/view/348
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