A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes

Abstract Background Transfer RNA-derived fragments (tRFs) are a new class of small non-coding RNAs. Recent studies suggest that tRFs participate in some pathological processes. However, the biological functions and mechanisms of tRFs in non-small cell lung cancer (NSCLC) are largely unknown. Methods...

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Main Authors: Wenhan Yang, Kaiping Gao, Youhui Qian, Yongyi Huang, Qin Xiang, Cheng Chen, Qianqian Chen, Yiling Wang, Fuyuan Fang, Qihan He, Siqi Chen, Juan Xiong, Yangchao Chen, Ni Xie, Duo Zheng, Rihong Zhai
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2022-05-01
Series:Journal of Hematology & Oncology
Assuntos:
tRNA-derived fragments
AS-tDR-007333
MED29
HSPB1
ELK4
Non-small cell lung cancer
Acceso en liña:https://doi.org/10.1186/s13045-022-01270-y
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