Epidural adipose tissue-derived mesenchymal stem cell activation induced by lung cancer cells promotes malignancy and EMT of lung cancer

Abstract Background Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit cancer-promoting properties that influence the tumour microenvironment; ho...

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Main Authors: Yan Wang, Yijing Chu, Xianfeng Ren, Hongfei Xiang, Yongming Xi, Xuexiao Ma, Kai Zhu, Zhu Guo, Chuanli Zhou, Guoqing Zhang, Bohua Chen
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-06-01
Series:Stem Cell Research & Therapy
Assuntos:
Metastatic epidural spinal cord compression
Adipose-derived mesenchymal stem cells
Pre-metastatic niches
Lung cancer
STAT3 signalling pathway
Acceso en liña:http://link.springer.com/article/10.1186/s13287-019-1280-3
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