In vivo delta opioid receptor internalization controls behavioral effects of agonists.

GPCRs regulate a remarkable diversity of biological functions, and are thus often targeted for drug therapies. Stimulation of a GPCR by an extracellular ligand triggers receptor signaling via G proteins, and this process is highly regulated. Receptor activation is typically accompanied by desensitiz...

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Hauptverfasser: Amynah A A Pradhan, Jérôme A J Becker, Grégory Scherrer, Petra Tryoen-Toth, Dominique Filliol, Audrey Matifas, Dominique Massotte, Claire Gavériaux-Ruff, Brigitte L Kieffer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2009-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC2672171?pdf=render
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