The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma

Interleukin-1 (IL-1) plays a key role in carcinogenesis and several IL-1-targeted therapeutics are under investigation for the treatment of pancreatic ductal adenocarcinoma (PDAC). We sought to broaden our understanding of how the family of IL-1 ligands and receptors impact the tumor immune landscap...

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Hlavní autoři: Kelly M. Herremans, Dominique D. Szymkiewicz, Andrea N. Riner, Riley P. Bohan, Gerik W. Tushoski, Aaron M. Davidson, XiangYang Lou, Man Chong Leong, Bayli DiVita Dean, Michael Gerber, Patrick W. Underwood, Song Han, Steven J. Hughes
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2022-06-01
Edice:Neoplasia: An International Journal for Oncology Research
Témata:
Pancreas cancer
Bioinformatics
Immunology
Immune checkpoint
Survival
On-line přístup:http://www.sciencedirect.com/science/article/pii/S1476558622000185
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