Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

Abstract Background Pancreatic cancer is a devastating disease that is characterized by persistent hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α, although both are critical for tumor cells to adapt to the hypoxic microenvironment. However, unlike the wel...

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Autori principali: Qi Zhang, Yu Lou, Jingying Zhang, Qihan Fu, Tao Wei, Xu Sun, Qi Chen, Jiaqi Yang, Xueli Bai, Tingbo Liang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2017-07-01
Serie:Molecular Cancer
Soggetti:
EPAS1
PDAC
Protein interaction
Cancer stem cell
Metabolic shift
Accesso online:http://link.springer.com/article/10.1186/s12943-017-0689-5
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