Novel Role of p53 in Septic Immunosuppression: Involvement in Loss and Dysfunction of CD4+ T Lymphocytes

Background/Aims: Immunosuppression frequently occurs during the development of sepsis and is closely associated with poor outcome. Characteristics of immunosuppressive CD4+ T lymphocytes in sepsis have been reported to include dramatic cell loss and inactivation. p53 acts as a pivotal transcription...

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Hlavní autoři: Hui Zhang, Cheng-Feng Xu, Chao Ren, Tian-Tian Wu, Ning Dong, Yong-Ming Yao
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Edice:Cellular Physiology and Biochemistry
Témata:
p53
CD4+ T lymphocytes
Cell proliferation
Apoptosis
Immunosuppression
Sepsis
On-line přístup:https://www.karger.com/Article/FullText/495241
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