The nonequilibrium mechanism of noise-enhanced drug synergy in HIV latency reactivation

Summary: Noise-modulating chemicals can synergize with transcriptional activators in reactivating latent HIV to eliminate latent HIV reservoirs. To understand the underlying biomolecular mechanism, we investigate a previous two-gene-state model and identify two necessary conditions for the synergy:...

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Hlavní autoři: Xiaolu Guo, Tao Tang, Minxuan Duan, Lei Zhang, Hao Ge
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2022-06-01
Edice:iScience
Témata:
Drugs
Virology
Mathematical biosciences
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2589004222006290
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