Differentiation and Functionality of Bone Marrow-Derived Mast Cells Depend on Varying Physiologic Oxygen Conditions

Mast cells (MCs) are long-living multifunctional innate immune cells that originate from hematopoietic precursors and specifically differentiate in the destination tissue, e.g., skin, respiratory mucosa, intestine, where they mediate immune cell recruitment and antimicrobial defense. In vivo these t...

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Bibliografiska uppgifter
Huvudupphovsmän: Helene Möllerherm, Karsten Meier, Kathrin Schmies, Herbert Fuhrmann, Hassan Y. Naim, Maren von Köckritz-Blickwede, Katja Branitzki-Heinemann
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2017-11-01
Serie:Frontiers in Immunology
Ämnen:
mast cells
physioxia
HIF-1α
FOXO3
histamine
reactive oxygen species
Länkar:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01665/full
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