Differentiation and Functionality of Bone Marrow-Derived Mast Cells Depend on Varying Physiologic Oxygen Conditions

Mast cells (MCs) are long-living multifunctional innate immune cells that originate from hematopoietic precursors and specifically differentiate in the destination tissue, e.g., skin, respiratory mucosa, intestine, where they mediate immune cell recruitment and antimicrobial defense. In vivo these t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Helene Möllerherm, Karsten Meier, Kathrin Schmies, Herbert Fuhrmann, Hassan Y. Naim, Maren von Köckritz-Blickwede, Katja Branitzki-Heinemann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2017-11-01
Cyfres:Frontiers in Immunology
Pynciau:
mast cells
physioxia
HIF-1α
FOXO3
histamine
reactive oxygen species
Mynediad Ar-lein:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01665/full
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