Differentiation and Functionality of Bone Marrow-Derived Mast Cells Depend on Varying Physiologic Oxygen Conditions

Mast cells (MCs) are long-living multifunctional innate immune cells that originate from hematopoietic precursors and specifically differentiate in the destination tissue, e.g., skin, respiratory mucosa, intestine, where they mediate immune cell recruitment and antimicrobial defense. In vivo these t...

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Main Authors: Helene Möllerherm, Karsten Meier, Kathrin Schmies, Herbert Fuhrmann, Hassan Y. Naim, Maren von Köckritz-Blickwede, Katja Branitzki-Heinemann
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017-11-01
Serier:Frontiers in Immunology
Fag:
mast cells
physioxia
HIF-1α
FOXO3
histamine
reactive oxygen species
Online adgang:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01665/full
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