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Knockdown of AKT3 (PKBγ) and PI3KCA Suppresses Cell Viability and Proliferation and Induces the Apoptosis of Glioblastoma Multiforme T98G Cells

Glioblastoma multiforme (GBM) is the most malignant and invasive human brain tumor that is difficult to treat and has a very poor prognosis. Thus, new therapeutic strategies that target GBM are urgently needed. The PI3K/AKT/PTEN signaling pathway is frequently deregulated in a wide range of cancers....

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Sonraí Bibleagrafaíochta
Main Authors: Monika Paul-Samojedny, Renata Suchanek, Paulina Borkowska, Adam Pudełko, Aleksander Owczarek, Małgorzata Kowalczyk, Grzegorz Machnik, Anna Fila-Daniłow, Jan Kowalski
Formáid: Artigo
Teanga:Inglês
Foilsithe: Hindawi Limited 2014-01-01
Sraith:BioMed Research International
Rochtain Ar Líne:http://dx.doi.org/10.1155/2014/768181
Clibeanna: Cuir Clib Leis
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