Knockdown of AKT3 (PKBγ) and PI3KCA Suppresses Cell Viability and Proliferation and Induces the Apoptosis of Glioblastoma Multiforme T98G Cells

Glioblastoma multiforme (GBM) is the most malignant and invasive human brain tumor that is difficult to treat and has a very poor prognosis. Thus, new therapeutic strategies that target GBM are urgently needed. The PI3K/AKT/PTEN signaling pathway is frequently deregulated in a wide range of cancers....

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Main Authors: Monika Paul-Samojedny, Renata Suchanek, Paulina Borkowska, Adam Pudełko, Aleksander Owczarek, Małgorzata Kowalczyk, Grzegorz Machnik, Anna Fila-Daniłow, Jan Kowalski
Format: Artigo
Language:Inglês
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/768181
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