GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome

Summary: Gut dysmotility is associated with constipation, diarrhea, and functional gastrointestinal disorders like irritable bowel syndrome (IBS), although its molecular underpinnings are poorly characterized. We studied stool frequency (defined by the number of bowel movements per day, based on que...

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Main Authors: Ferdinando Bonfiglio, Xingrong Liu, Christopher Smillie, Anita Pandit, Alexander Kurilshikov, Rodrigo Bacigalupe, Tenghao Zheng, Hieu Nim, Koldo Garcia-Etxebarria, Luis Bujanda, Anna Andreasson, Lars Agreus, Susanna Walter, Gonçalo Abecasis, Chris Eijsbouts, Luke Jostins, Miles Parkes, David A. Hughes, Nicholas Timpson, Jeroen Raes, Andre Franke, Nicholas A. Kennedy, Aviv Regev, Alexandra Zhernakova, Magnus Simren, Michael Camilleri, Mauro D’Amato
Format: Artigo
Language:Inglês
Published: Elsevier 2021-12-01
Series:Cell Genomics
Subjects:
gut motility
GWAS
SNP
irritable bowel syndrome
polygenic scores
genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X21000859
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