Biomarkers for Immune Checkpoint Inhibitor-Mediated Tumor Response and Adverse Events

In the last decade, inhibitors targeting immune checkpoint molecules such as cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1), and programmed cell death-ligand 1 (PD-L1) brought about a major paradigm shift in cancer treatment. These immune checkpoint inhibitors (ICIs) impro...

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Bibliographische Detailangaben
1. Verfasser: Yoshiyuki Nakamura
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-05-01
Schriftenreihe:Frontiers in Medicine
Schlagworte:
immune check point inhibitor
adverse event (AE)
PD-1
CTLA- 4
tumor response
Online Zugang:https://www.frontiersin.org/article/10.3389/fmed.2019.00119/full
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