The Effects of Mechanical Stretch on Integrins and Filopodial-Associated Proteins in Normal and Glaucomatous Trabecular Meshwork Cells

The trabecular meshwork (TM) is the tissue responsible for regulating aqueous humor fluid egress from the anterior eye. If drainage is impaired, intraocular pressure (IOP) becomes elevated, which is a primary risk factor for primary open angle glaucoma. TM cells sense elevated IOP via changes in the...

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Bibliographic Details
Main Authors: Yong-Feng Yang, Ying Ying Sun, Donna M. Peters, Kate E. Keller
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glaucoma
trabecular meshwork
filopodia
integrins
tunneling nanotubes
myosin-X
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.886706/full
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