Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor

Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date. A similar pathological model is reconstructed here by using human N...

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Bibliografiske detaljer
Main Authors:	Lu Qiu, Meng Wang, Shaofan Hu, Xufang Ru, Yonggang Ren, Zhengwen Zhang, Siwang Yu, Yiguo Zhang
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2018-12-01
Serier:	Cancers
Fag:	Nrf1α Nrf2 Keap1 PTEN COX1 COX2 AP-1 miR-22 proteasome tumor repressor tumor promoter regulatory networks non-alcoholic steatohepatitis hepatoma oxidative stress
Online adgang:	https://www.mdpi.com/2072-6694/10/12/520
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Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor

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