Dynamic expression of Notch signaling genes in neural stem/progenitor cells

In neural stem/progenitor cells, expression of the Notch effector Hes1, a transcriptional repressor, oscillates with a period of 2-3 hours by negative feedback, and Hes1 oscillations induce the oscillatory expression of the proneural gene Neurogenin2 (Ngn2) and the Notch ligand gene Delta-like1 (Dll...

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Hauptverfasser: Hiromi eShimojo, Toshiyuki eOhtsuka, Ryoichiro eKageyama
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2011-06-01
Schriftenreihe:Frontiers in Neuroscience
Schlagworte:
lateral inhibition
neural stem cell
Delta-like1
Hes1
neural progenitor cell
neurogenin
Online Zugang:http://journal.frontiersin.org/Journal/10.3389/fnins.2011.00078/full
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