Uncovering the Signaling Pathway behind Extracellular Guanine-Induced Activation of NO System: New Perspectives in Memory-Related Disorders

Mounting evidence suggests that the guanine-based purines stand out as key player in cell metabolism and in several models of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. Guanosine (GUO) and guanine (GUA) are extracellular signaling molecules derived from the breakdown...

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Bibliographic Details
Main Authors: Mariachiara Zuccarini, Patricia Giuliani, Monica Frinchi, Giuseppa Mudò, Rosa Maria Serio, Natale Belluardo, Silvana Buccella, Marzia Carluccio, Daniele F. Condorelli, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
guanine
L-NAME
nitric oxide
cGMP
ERK
SH-SY5Y cell line
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00110/full
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