DIRECT: RNA contact predictions by integrating structural patterns

Abstract Background It is widely believed that tertiary nucleotide-nucleotide interactions are essential in determining RNA structure and function. Currently, direct coupling analysis (DCA) infers nucleotide contacts in a sequence from its homologous sequence alignment across different species. DCA...

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Hauptverfasser: Yiren Jian, Xiaonan Wang, Jaidi Qiu, Huiwen Wang, Zhichao Liu, Yunjie Zhao, Chen Zeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2019-10-01
Schriftenreihe:BMC Bioinformatics
Schlagworte:
RNA
Restricted Boltzmann machine
Coevolution
Nucleotide-nucleotide interaction
Online Zugang:http://link.springer.com/article/10.1186/s12859-019-3099-4
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