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Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas
Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs. WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor. Loss of WWOX gene exp...
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| Main Authors: | , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Frontiers Media S.A.
2013-03-01
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| 叢編: | Frontiers in Oncology |
| 主題: | |
| 在線閱讀: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00043/full |
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