Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs. WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor. Loss of WWOX gene exp...

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Main Authors: Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2013-03-01
Sraith:Frontiers in Oncology
Ábhair:
p53
tumor suppressor
Glioblastoma Multiforme
WWOX
temozolomide resistance
Rochtain Ar Líne:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00043/full
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