Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs. WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor. Loss of WWOX gene exp...

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Bibliographic Details
Main Authors: Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Oncology
Subjects:
p53
tumor suppressor
Glioblastoma Multiforme
WWOX
temozolomide resistance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00043/full
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