Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs. WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor. Loss of WWOX gene exp...

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Hlavní autoři: Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2013-03-01
Edice:Frontiers in Oncology
Témata:
p53
tumor suppressor
Glioblastoma Multiforme
WWOX
temozolomide resistance
On-line přístup:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00043/full
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