Evaluation of Aptamers as Affinity Reagents for an Enhancement of SRM-Based Detection of Low-Abundance Proteins in Blood Plasma

Selected reaction monitoring (SRM) is a mass spectrometric technique characterized by the exceptionally high selectivity and sensitivity of protein detection. However, even with this technique, the quantitative detection of low- and ultralow-abundance proteins in blood plasma, which is of great impo...

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Hauptverfasser: Sergey Radko, Konstantin Ptitsyn, Svetlana Novikova, Yana Kiseleva, Alexander Moysa, Leonid Kurbatov, Maria Mannanova, Victor Zgoda, Elena Ponomarenko, Andrey Lisitsa, Alexander Archakov
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-05-01
Schriftenreihe:Biomedicines
Schlagworte:
selected reaction monitoring
protein detection
blood plasma
SMAD4
aptamer-based affinity enrichment
Online Zugang:https://www.mdpi.com/2227-9059/8/5/133
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