Lactate promotes the growth of patient-derived organoids from hepatopancreatobiliary cancers via ENO1/HIF1α pathway and does not affect their drug sensitivities

Abstract The long culture duration of patient-derived organoids (PDOs) have severely limited their clinical applications. The aim of this study was to determine the effect of lactate supplementation on the growth, genetic profiles and drug sensitivities of PDOs from hepatopancreatobiliary tumors. LM...

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Главные авторы: Zhiwei Wang, Yuanquan Yu, Peiyao Wu, Qinghuang Ye, Yinghao Guo, Xiaoxiao Zhang, Longfu Xi, Qi Li, Yun Jin, Donger Zhou, Yan Luo, Shuyou Peng, Jiangtao Li
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2022-04-01
Серии:Cell Death Discovery
Online-ссылка:https://doi.org/10.1038/s41420-022-01014-4
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