Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function

Regulatory T cells (Treg cells) are essential for maintaining immune tolerance, and the dysfunction of Treg cells may cause autoimmune diseases and tumors. Forkhead box P3 (FOXP3) is the key transcription factor controlling Treg cell development and suppressive function. Mouse double minute 2 homolo...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Aiting Wang, Mengdi Yang, Rui Liang, Fangming Zhu, Fuxiang Zhu, Xinnan Liu, Yichao Han, Ruirong Lin, Xiaoxia Wang, Dan Li, Hecheng Li, Xiaojun Yuan, Hui Zhao, Bin Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020-06-01
Edice:Frontiers in Immunology
Témata:
E3 ubiquitin ligase
forkhead box P3 (FOXP3)
immunosuppression
mouse double minute 2 homolog (MDM2)
regulatory T cell (Treg cell)
ubiquitination
On-line přístup:https://www.frontiersin.org/article/10.3389/fimmu.2020.01087/full
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky