Stachydrine Ameliorates Cardiac Fibrosis Through Inhibition of Angiotensin II/Transformation Growth Factor β1 Fibrogenic Axis

Cardiovascular diseases, the leading cause of death worldwide, are tightly associated with the pathological myocardial fibrosis. Stachydrine (Sta), a major active compound in Chinese motherwort Leonurus heterophyllus, was reported to effectively attenuate cardiac fibrosis, but the cellular and molec...

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Auteurs principaux: Xiao Liu, Xiaoli Shan, Huihua Chen, Zan Li, Pei Zhao, Chen Zhang, Wei Guo, Ming Xu, Rong Lu
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019-05-01
Collection:Frontiers in Pharmacology
Sujets:
cardiac fibrosis
cardiac fibroblasts
myofibroblasts
angiotensin II
transformation growth factor-β1
Smads
Accès en ligne:https://www.frontiersin.org/article/10.3389/fphar.2019.00538/full
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