A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal

Pancreatic cancer is one of the most lethal common cancers. The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial, and recent evidence suggested acinar cells as the most probable candidate. However, the genetic alterations driving the transformation of pancreatic acina...

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Main Authors: Qiu Tu, Dong Yang, Xianning Zhang, Xintong Jia, Sanqi An, Lanzhen Yan, Hongjuan Dai, Yuhua Ma, Chengwei Tang, Weimin Tong, Zongliu Hou, Longbao Lv, Jing Tan, Xudong Zhao
格式: Artigo
語言:Inglês
出版: The Company of Biologists 2019-04-01
叢編:Disease Models & Mechanisms
主題:
Pancreatic cancer
Animal model
Tree shrew
Acinar cells
Cdkn2b
在線閱讀:http://dmm.biologists.org/content/12/4/dmm038703
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