Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response

Abstract Background Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the potential culprit in ICI resistance, but direct clinical evidence is lacking. Methods Publicly available scR...

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Main Authors: Zhen Zhang, Zi-Xian Wang, Yan-Xing Chen, Hao-Xiang Wu, Ling Yin, Qi Zhao, Hui-Yan Luo, Zhao-Lei Zeng, Miao-Zhen Qiu, Rui-Hua Xu
Format: Artigo
Jezik:Inglês
Izdano: BMC 2022-04-01
Serija:Genome Medicine
Teme:
Big data analysis
Single-cell sequencing
Immune checkpoint therapy
Stemness
Pan-cancer
Online dostop:https://doi.org/10.1186/s13073-022-01050-w
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