Design, Physicochemical Characterization, and In Vitro Permeation of Innovative Resatorvid Topical Formulations for Targeted Skin Drug Delivery

Nonmelanoma skin cancers (NMSCs) are the most common malignancies worldwide and affect more than 5 million people in the United States every year. NMSC is directly linked to the excessive exposure of the skin to solar ultraviolet (UV) rays. The toll-like receptor 4 (TLR4) antagonist, resatorvid (TAK...

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Bibliographic Details
Main Authors: Victor H. Ruiz, David Encinas-Basurto, Bo Sun, Basanth Babu Eedara, Sally E. Dickinson, Georg T. Wondrak, H. -H. Sherry Chow, Clara Curiel-Lewandrowski, Heidi M. Mansour
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
resatorvid (TAK-242)
nonmelanoma skin cancers
topical drug delivery
HaCaT human skin cell line
NHEK normal primary human skin cells
Strat-M synthetic membrane
Online Access:https://www.mdpi.com/1999-4923/14/4/700
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