Integrated Network Pharmacology Approach for Drug Combination Discovery: A Multi-Cancer Case Study

Despite remarkable efforts of computational and predictive pharmacology to improve therapeutic strategies for complex diseases, only in a few cases have the predictions been eventually employed in the clinics. One of the reasons behind this drawback is that current predictive approaches are based on...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Antonio Federico, Michele Fratello, Giovanni Scala, Lena Möbus, Alisa Pavel, Giusy del Giudice, Michele Ceccarelli, Valerio Costa, Alfredo Ciccodicola, Vittorio Fortino, Angela Serra, Dario Greco
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-04-01
Schriftenreihe:Cancers
Schlagworte:
druggability
network
systems pharmacology
cancer
cancer therapy
drug repositioning
Online Zugang:https://www.mdpi.com/2072-6694/14/8/2043
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