Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism

With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate the interaction mechanisms between them, a pannel of 70 structurally diverse flavonoids was used to evaluate their inhibitory activities against DPP-4, among whic...

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Main Authors: Junkun Pan, Qiang Zhang, Chunling Zhang, Wenbo Yang, Hui Liu, Zhenzhen Lv, Jiechao Liu, Zhonggao Jiao
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2022-05-01
Serija:Frontiers in Nutrition
Teme:
flavonoid
dipeptidyl peptidase-4
inhibition
structure-activity relationship
kinetics
binding
Online dostop:https://www.frontiersin.org/articles/10.3389/fnut.2022.892426/full
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