Comparison of natural and artificial vasopressin deficiency: why the latter is lethal?

The transgenic mouse technology is widespread, however, untill now 22.0 % of tested null mutations was found to be lethal. The complete lack of vasopressin (AVP) resulted also in preweaning lethality. It is surprising take into consideration the viability of the AVP mutant Brattleboro rats. Thus, AV...

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Bibliographic Details
Main Author: D. Zelena
Format: Artigo
Language:Inglês
Published: Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2016-05-01
Series:Vavilovskij Žurnal Genetiki i Selekcii
Subjects:
brattleboro rat, vasopressin knockout mice, vasopressin gene, vasopressin receptors, hypovolaemia.
Online Access:https://vavilov.elpub.ru/jour/article/view/590
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